"In United States history, Kamala Harris is uniquely first in all, but ..."
A 1st Black and South Asian Vice President.
B 1st Female Vice President.
C 1st Female Vice President.1st woman to hold powers of the presidency.
(Nov 19, 2021, President Biden briefly transferred the power of the presidency to V.P. Kamala Harris before going under anesthesia for a medical procedure, making Harris the first woman (and of color) to hold powers of the presidency—for 85 minutes.)
D 1st Black S.L.O.T.U.S.
Kamala Harris isn't the 1st Black Second Lady of the United States; however, Dough Emhoff—her spouse—is the first Second Gentleman of the United States.